CCDC186

Across TCGA patient cohorts, CCDC186 mutation is significantly associated with the RNA expression of many other genes, with 5,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC186-associated genes across cancer lineages are MRPL54, SNRPD3, and PSMC6. Each is linked with CCDC186 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC186-to-partner and partner-to-CCDC186 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL54 grouped by CCDC186-low versus CCDC186-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC186→partner) and Y-score (partner→CCDC186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL54 →	+0.409	+3.010	.001	<.001	3	3
UCEC	SNRPD3 →	+0.313	+2.222	.001	<.001	3	3
UCEC	PSMC6 →	+0.387	+3.180	.001	<.001	3	3
UCEC	EIF5 →	+0.385	+2.938	.002	<.001	3	3
UCEC	ZC3H14 →	+0.381	+1.968	<.001	<.001	3	3
UCEC	TTC1 →	+0.313	+1.754	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,579 associations by consensus.

MRPL54 by CCDC186 expression — UCEC

Explore this box plot interactively →