CCDC185

Across TCGA patient cohorts, CCDC185 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC185-associated genes across cancer lineages are JNK_pT183_Y185, eEF2K, and eIF4G. Each is linked with CCDC185 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC185-to-partner and partner-to-CCDC185 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CCDC185-low versus CCDC185-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC185→partner) and Y-score (partner→CCDC185) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.163	-2.000	.019	.030	3	2
UCEC	eEF2K →	+0.295	+3.169	.040	.019	3	2
UCEC	eIF4G →	+0.299	+2.459	.019	.019	3	1
UCEC	ERK2 →	+0.210	+3.321	.008	.010	2	2
UCEC	MSH6 →	-0.284	-2.321	.037	.033	3	1
UCEC	Notch1 →	+0.184	+2.335	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK_pT183_Y185 by CCDC185 expression — UCEC

Explore this box plot interactively →