CCDC185

Across TCGA pan-cancer cohorts, CCDC185 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CCDC185’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC185 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC185 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where CCDC185 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC185 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	+0.103	<.001	8	view →
KICH	Male	All	−0.767	<.001	7	view →
LUAD	Female	All	+0.562	<.001	7	view →
LUSC	Male	All	+0.340	<.001	7	view →
KIRC	Male	II,III,IV	−0.332	<.001	7	view →
BRCA	Female	II,III,IV	+0.211	<.001	6	view →
UCEC	All	All	+0.216	.006	4	view →
LIHC	All	All	+0.106	.006	2	view →
CHOL	Male	All	+0.224	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CCDC185–THCA

Open the THCA breakdown →