CCDC185

Across TCGA cell cohorts, CCDC185 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,569 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CCDC185-associated GO terms across cancer lineages are Positive regulation of protein localization to nucleus, Regulation of stem cell population maintenance, and Protein-RNA complex assembly. Each is linked with CCDC185 in more than 8 cancer types. Because this analysis shows association rather than direction, both CCDC185-to-partner and partner-to-CCDC185 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to nucleus grouped by CCDC185-low versus CCDC185-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC185→partner) and Y-score (partner→CCDC185) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of protein localization to nucleus →	+0.061	+0.149	<.001	<.001	3	8
BREAST	Regulation of stem cell population maintenance →	+0.054	+0.152	.001	.007	3	8
LUNG_SCLC	Protein-RNA complex assembly →	+0.074	+0.133	<.001	<.001	3	8
OVARY	Alternative mRNA splicing, via spliceosome →	+0.106	+0.120	<.001	.002	2	9
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.083	+0.238	.001	.009	2	9
BREAST	Negative regulation of complement activation, alternative pathway →	+1.798	+0.330	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,569 associations by consensus.

Positive regulation of protein localization to nucleus by CCDC185 expression — LUNG_NSCLC_LUAD

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