CCDC178

Across TCGA patient cohorts, CCDC178 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,162 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CCDC178-associated GO terms across cancer lineages are Atrioventricular valve development, Pulmonary valve development, and Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Each is linked with CCDC178 in more than 23 cancer types. Because this analysis shows association rather than direction, both CCDC178-to-partner and partner-to-CCDC178 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Atrioventricular valve development grouped by CCDC178-low versus CCDC178-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC178→partner) and Y-score (partner→CCDC178) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Atrioventricular valve development →	+0.066	+0.156	<.001	<.001	3	24
ESCA	Pulmonary valve development →	+0.085	+0.238	<.001	<.001	3	23
STAD	Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.055	+0.210	<.001	<.001	3	23
STAD	Heart morphogenesis →	+0.052	+0.177	<.001	<.001	3	22
ESCA	Heart valve morphogenesis →	+0.075	+0.185	<.001	<.001	3	22
STAD	Cardiac chamber development →	+0.051	+0.191	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,162 associations by consensus.

Atrioventricular valve development by CCDC178 expression — ESCA

Explore this box plot interactively →