CCDC178

Across TCGA pan-cancer cohorts, CCDC178 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CCDC178 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CCDC178 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CCDC178 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRC, PAAD, and UCS are the cancer types where CCDC178 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.706	0.533	<.001	121	view →
PAAD	DFS	Quartile	All	0.619	0.234	<.001	56	view →
UCS	DFS	Tertile	II,III,IV	0.615	0.116	.001	48	view →
KIRP	DFS	Median	All	0.944	0.591	<.001	48	view →
LGG	OS	Median	All	0.880	0.738	<.001	45	view →
BLCA	OS	Tertile	IV	0.134	0.414	.008	43	view →
CHOL	DFS	Quartile	All	1.000	0.240	.005	34	view →
ACC	DFS	Quartile	All	0.308	0.754	.002	30	view →
STAD	DFS	Median	All	0.472	0.622	.001	28	view →
SKCM	DFS	Tertile	III,IV	0.447	0.692	<.001	28	view →
ESCA	DFS	Quartile	II,III,IV	0.716	0.475	.017	21	view →
SARC	DFS	Tertile	All	0.452	0.264	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CCDC178–KIRC (OS)

Open the KIRC breakdown →