CCDC178

Across TCGA patient cohorts, CCDC178 mutation is significantly associated with the RNA expression of many other genes, with 3,486 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC178-associated genes across cancer lineages are RRP9, MEA1, and ATP1B2. Each is linked with CCDC178 in more than 4 cancer types. Because this analysis shows association rather than direction, both CCDC178-to-partner and partner-to-CCDC178 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RRP9 grouped by CCDC178-low versus CCDC178-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC178→partner) and Y-score (partner→CCDC178) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP9 →	+0.405	+3.140	<.001	<.001	3	5
SKCM	MEA1 →	+0.302	+2.360	.001	<.001	3	4
UCEC	ATP1B2 →	-0.723	-4.159	<.001	<.001	3	4
UCEC	TRIP13 →	+0.487	+2.839	.009	.001	3	4
UCEC	METTL5 →	+0.433	+2.399	<.001	<.001	3	4
UCEC	RNASEH2A →	+0.425	+2.839	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,486 associations by consensus.

RRP9 by CCDC178 expression — UCEC

Explore this box plot interactively →