CCDC178

Across TCGA cell cohorts, CCDC178 mutation is significantly associated with the RNA expression of many other genes, with 427 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC178-associated genes across cancer lineages are DEFB126, SEPTIN14, and TNFRSF13B. Each is linked with CCDC178 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC178-to-partner and partner-to-CCDC178 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB126 grouped by CCDC178-low versus CCDC178-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC178→partner) and Y-score (partner→CCDC178) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB126 →	+0.546	+3.215	<.001	.007	3	2
SOFT_TISSUE	SEPTIN14 →	+0.005	+3.882	<.001	.004	3	2
SOFT_TISSUE	TNFRSF13B →	+0.146	+3.966	<.001	.004	3	2
BLOOD_Leukemia	HHLA1 →	+0.005	+2.644	<.001	.008	3	2
LUNG_SCLC	PAGE4 →	+0.309	+2.591	<.001	.001	3	2
BLOOD_Myeloma	ASB10 →	+0.023	+3.285	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 427 associations by consensus.

DEFB126 by CCDC178 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →