CCDC177

Across TCGA cell cohorts, CCDC177 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,923 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CCDC177-associated GO terms across cancer lineages are Positive regulation of cation transmembrane transport, Positive regulation of monoatomic ion transmembrane transport, and Regulation of calcium ion transport into cytosol. Each is linked with CCDC177 in more than 6 cancer types. Because this analysis shows association rather than direction, both CCDC177-to-partner and partner-to-CCDC177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cation transmembrane transport grouped by CCDC177-low versus CCDC177-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC177→partner) and Y-score (partner→CCDC177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of cation transmembrane transport →	-0.101	-0.021	<.001	.003	3	7
BONE	Positive regulation of monoatomic ion transmembrane transport →	-0.115	-0.357	<.001	.004	3	7
LUNG_SCLC	Regulation of calcium ion transport into cytosol →	-0.350	-1.642	<.001	<.001	3	7
BONE	Cell cycle phase transition →	+0.089	+0.248	<.001	.006	3	7
LUNG_SCLC	Purine nucleoside triphosphate metabolic process →	+0.066	+1.200	.003	.001	3	7
LUNG_SCLC	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.130	+1.700	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,923 associations by consensus.

Positive regulation of cation transmembrane transport by CCDC177 expression — PANCREAS

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