CCDC177

Across TCGA cell cohorts, CCDC177 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC177-associated genes across cancer lineages are CD40LG, MAGEB4, and OR2AT4. Each is linked with CCDC177 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC177-to-partner and partner-to-CCDC177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by CCDC177-low versus CCDC177-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC177→partner) and Y-score (partner→CCDC177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CD40LG →	+0.017	+5.614	<.001	<.001	3	1
LUNG_SCLC	MAGEB4 →	+0.005	+4.643	<.001	.004	3	1
LARGE_INTESTINE	OR2AT4 →	+0.015	+3.196	.006	.007	3	1
LARGE_INTESTINE	FAM187B →	+0.020	+3.347	.003	.005	3	1
LARGE_INTESTINE	DAZ4 →	+0.164	+3.977	<.001	.001	3	1
LARGE_INTESTINE	TAS2R41 →	+0.040	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CD40LG by CCDC177 expression — LUNG_SCLC

Explore this box plot interactively →