CCDC175

Across TCGA cell cohorts, CCDC175 mutation is significantly associated with the mutation status of many other genes, with 1,711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC175-associated genes across cancer lineages are SEMA5A, ACVR2A, and KIF24. Each is linked with CCDC175 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC175-to-partner and partner-to-CCDC175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA5A grouped by CCDC175-low versus CCDC175-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC175→partner) and Y-score (partner→CCDC175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SEMA5A →	+4.437	+5.000	.007	.007	1	4
LUNG_SCLC	ACVR2A →	+5.066	+4.502	.007	.007	1	4
BONE	KIF24 →	+5.437	+5.437	.003	.003	1	3
LUNG_SCLC	GAL3ST3 →	+5.066	+4.502	.007	.007	1	3
OVARY	ANKRD27 →	+4.415	+4.977	.007	.007	1	3
LARGE_INTESTINE	CDH23 →	+1.347	+3.485	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,711 associations by consensus.

SEMA5A by CCDC175 expression — BONE

Explore this box plot interactively →