CCDC173

Across TCGA patient cohorts, CCDC173 mutation is significantly associated with the RNA expression of many other genes, with 1,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC173-associated genes across cancer lineages are UHRF1, MIR6803, and RNU6-178P. Each is linked with CCDC173 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC173-to-partner and partner-to-CCDC173 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by CCDC173-low versus CCDC173-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC173→partner) and Y-score (partner→CCDC173) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.685	+2.081	.002	.001	3	2
UCEC	MIR6803 →	+0.082	+3.893	<.001	.006	3	2
READ	RNU6-178P →	+0.578	+4.361	<.001	.006	3	2
UCEC	OIP5 →	+0.668	+2.431	.001	.001	3	2
UCEC	PSMC3IP →	+0.467	+2.111	.004	.003	3	2
UCEC	ZNF667 →	-1.071	-2.927	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,227 associations by consensus.

UHRF1 by CCDC173 expression — UCEC

Explore this box plot interactively →