CCDC173

Across TCGA patient cohorts, CCDC173 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC173-associated genes across cancer lineages are p27_pT198, EGFR_pY1068, and EGFR_pY1173. Each is linked with CCDC173 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC173-to-partner and partner-to-CCDC173 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by CCDC173-low versus CCDC173-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC173→partner) and Y-score (partner→CCDC173) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.099	+2.999	.018	.035	3	2
UCEC	EGFR_pY1068 →	-0.197	-2.000	.046	.010	3	1
UCEC	EGFR_pY1173 →	+0.089	+2.026	.004	.005	3	1
UCEC	eIF4G →	+0.324	+3.459	.007	.005	3	1
UCEC	ER-alpha_pS118 →	+0.288	+3.335	.041	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-3.459	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p27_pT198 by CCDC173 expression — UCEC

Explore this box plot interactively →