CCDC171

Across TCGA patient cohorts, CCDC171 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC171-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and p27_pT157. Each is linked with CCDC171 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC171-to-partner and partner-to-CCDC171 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CCDC171-low versus CCDC171-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC171→partner) and Y-score (partner→CCDC171) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.544	-3.000	<.001	.034	3	4
COAD	Caspase-7-cleavedD198 →	+1.181	+2.593	<.001	.006	3	3
COAD	p27_pT157 →	+0.138	+1.882	.023	.031	3	3
UCEC	eIF4E →	+0.149	+1.807	.017	<.001	3	2
UCEC	FASN →	+0.237	+1.502	.043	.027	3	2
UCEC	MEK1 →	+0.389	+1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by CCDC171 expression — COAD

Explore this box plot interactively →