CCDC170

Across TCGA patient cohorts, CCDC170 mutation is significantly associated with the RNA expression of many other genes, with 3,444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC170-associated genes across cancer lineages are MIR4259, CDK1, and WSB2. Each is linked with CCDC170 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC170-to-partner and partner-to-CCDC170 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4259 grouped by CCDC170-low versus CCDC170-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC170→partner) and Y-score (partner→CCDC170) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4259 →	+0.418	+4.655	<.001	<.001	3	3
SKCM	CDK1 →	+0.529	+1.799	.003	<.001	3	3
UCEC	WSB2 →	+0.520	+2.970	<.001	<.001	3	3
SKCM	BTBD6 →	+0.389	+1.328	.001	.008	3	3
SKCM	CYB5RL →	+0.407	+1.813	<.001	.003	3	3
SKCM	VTA1 →	+0.477	+2.958	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,444 associations by consensus.

MIR4259 by CCDC170 expression — HNSC

Explore this box plot interactively →