CCDC170

Across TCGA patient cohorts, CCDC170 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC170-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and Caveolin-1. Each is linked with CCDC170 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC170-to-partner and partner-to-CCDC170 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC170-low versus CCDC170-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC170→partner) and Y-score (partner→CCDC170) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Caspase-7-cleavedD198 →	+0.704	+3.468	.001	.002	3	3
UCEC	C-Raf →	+0.211	+2.584	<.001	.010	3	3
SKCM	Caveolin-1 →	-0.572	-1.925	.010	.004	3	3
LUSC	eEF2 →	+0.188	+2.331	.022	.019	3	2
UCEC	ERK2 →	+0.178	+2.000	.016	.030	3	2
SKCM	ACVRL1 →	-0.134	-1.925	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by CCDC170 expression — LUSC

Explore this box plot interactively →