CCDC170

Across TCGA cell cohorts, CCDC170 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,475 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC170-associated GO terms across cancer lineages are Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, Glycerophospholipid metabolic process, and Branched-chain amino acid metabolic process. Each is linked with CCDC170 in more than 5 cancer types. Because this analysis shows association rather than direction, both CCDC170-to-partner and partner-to-CCDC170 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay grouped by CCDC170-low versus CCDC170-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC170→partner) and Y-score (partner→CCDC170) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.098	+1.468	<.001	<.001	3	6
BREAST	Glycerophospholipid metabolic process →	+0.030	+0.956	.001	.004	3	6
BREAST	Branched-chain amino acid metabolic process →	+0.087	+1.020	.001	.002	3	6
BREAST	Branched-chain amino acid catabolic process →	+0.092	+1.010	<.001	.002	3	6
BONE	Response to progesterone →	+0.116	+0.394	.001	.008	3	6
SOFT_TISSUE	Golgi vesicle transport →	+0.052	+0.258	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,475 associations by consensus.

Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay by CCDC170 expression — BREAST

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