CCDC169-SOHLH2

Across TCGA pan-cancer cohorts, CCDC169-SOHLH2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated CCDC169-SOHLH2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CCDC169-SOHLH2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC169-SOHLH2 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

HNSC, UCS, and KIRC are the cancer types where CCDC169-SOHLH2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.223	0.400	<.001	141	view →
UCS	OS	Quartile	III,IV	0.759	0.249	<.001	80	view →
KIRC	DFS	Median	II,III,IV	0.640	0.340	<.001	50	view →
LUAD	DFS	Quartile	All	0.705	0.861	.001	33	view →
OV	DFS	Tertile	All	0.447	0.359	.026	30	view →
THCA	DFS	Tertile	All	0.765	0.903	.007	23	view →
ACC	OS	Tertile	II,III,IV	0.609	0.907	.018	21	view →
GBM	DFS	Median	All	0.268	0.164	.007	19	view →
DLBC	DFS	Tertile	All	0.022	0.809	<.001	18	view →
READ	OS	Tertile	III,IV	0.242	0.794	<.001	18	view →
LAML	DFS	Median	All	0.708	0.439	.006	16	view →
COAD	DFS	Tertile	III,IV	0.820	0.378	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

CCDC169-SOHLH2–HNSC (OS)

Open the HNSC breakdown →