CCDC158

Across TCGA patient cohorts, CCDC158 mutation is significantly associated with the RNA expression of many other genes, with 4,639 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC158-associated genes across cancer lineages are RCC1, C4orf46, and HAUS5. Each is linked with CCDC158 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC158-to-partner and partner-to-CCDC158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by CCDC158-low versus CCDC158-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC158→partner) and Y-score (partner→CCDC158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC1 →	+0.452	+1.747	<.001	<.001	3	3
UCEC	C4orf46 →	+0.595	+2.768	<.001	<.001	3	3
UCEC	HAUS5 →	+0.312	+1.380	.005	.004	3	3
COAD	GAS2L1 →	+0.605	+3.459	.007	.005	3	3
COAD	C7orf77 →	+0.134	+2.588	<.001	.009	3	3
UCEC	USP14 →	+0.384	+2.225	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,639 associations by consensus.

RCC1 by CCDC158 expression — UCEC

Explore this box plot interactively →