CCDC146

Across TCGA patient cohorts, CCDC146 mutation is significantly associated with the RNA expression of many other genes, with 3,919 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC146-associated genes across cancer lineages are MIR4265, IGKV2OR2-10, and KRTAP1-3. Each is linked with CCDC146 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC146-to-partner and partner-to-CCDC146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4265 grouped by CCDC146-low versus CCDC146-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC146→partner) and Y-score (partner→CCDC146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4265 →	+0.093	+3.610	<.001	.001	3	3
BRCA	IGKV2OR2-10 →	+0.203	+4.635	<.001	.004	3	2
GBM	KRTAP1-3 →	+0.075	+4.969	<.001	.009	3	2
GBM	OR1C1 →	+0.147	+5.584	<.001	.003	3	2
GBM	CYCSP48 →	+0.205	+5.584	<.001	.003	3	2
UCEC	SSRP1 →	+0.410	+2.170	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,919 associations by consensus.

MIR4265 by CCDC146 expression — SKCM

Explore this box plot interactively →