CCDC141

Across TCGA patient cohorts, CCDC141 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC141-associated genes across cancer lineages are PCNA, c-Kit, and FoxM1. Each is linked with CCDC141 in more than 4 cancer types. Because this analysis shows association rather than direction, both CCDC141-to-partner and partner-to-CCDC141 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CCDC141-low versus CCDC141-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC141→partner) and Y-score (partner→CCDC141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.211	+1.593	.030	.043	3	5
SKCM	c-Kit →	-0.480	-1.736	.005	.004	3	5
LUSC	FoxM1 →	+0.318	+2.124	.004	.010	3	4
COAD	Caspase-7-cleavedD198 →	+1.045	+2.123	<.001	.010	3	4
UCEC	MEK1 →	+0.452	+2.209	<.001	<.001	3	4
UCEC	ASNS →	+0.325	+1.289	<.001	.021	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

PCNA by CCDC141 expression — COAD

Explore this box plot interactively →