CCDC141

Across TCGA pan-cancer cohorts, CCDC141 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CCDC141 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CCDC141 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC141 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, LUSC, and HNSC are the cancer types where CCDC141 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.627	0.431	.001	84	view →
LUSC	OS	Quartile	All	0.308	0.519	.002	79	view →
HNSC	DFS	Tertile	II,III,IV	0.408	0.277	.005	41	view →
KIRP	OS	Tertile	All	0.330	0.782	<.001	35	view →
LGG	DFS	Median	All	0.800	0.674	<.001	30	view →
SKCM	OS	Median	All	0.405	0.282	.002	24	view →
SCLC	DFS	Median	III,IV	0.723	0.279	<.001	23	view →
CESC	DFS	Median	All	0.885	0.766	.005	22	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.125	.001	20	view →
ESCA	DFS	Median	III,IV	0.438	0.224	.003	18	view →
UVM	DFS	Median	III,IV	0.274	0.704	.007	17	view →
LIHC	OS	Median	III,IV	0.918	0.532	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CCDC141–KIRC (DFS)

Open the KIRC breakdown →