CCDC141

Across TCGA cell cohorts, CCDC141 mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC141-associated genes across cancer lineages are KAAG1, ALOXE3, and PRKAR2A. Each is linked with CCDC141 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC141-to-partner and partner-to-CCDC141 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAAG1 grouped by CCDC141-low versus CCDC141-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC141→partner) and Y-score (partner→CCDC141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KAAG1 →	+0.060	+3.440	<.001	.001	3	2
BLOOD_Leukemia	ALOXE3 →	+0.293	+3.554	<.001	.007	3	2
LARGE_INTESTINE	PRKAR2A →	+0.499	+3.252	.002	.002	3	2
LARGE_INTESTINE	COPG2 →	-0.605	-2.459	.002	.006	3	2
LARGE_INTESTINE	C2orf80 →	+0.011	+2.172	.006	.007	3	2
CNS	GAGE12D →	+0.508	+4.035	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

KAAG1 by CCDC141 expression — BLOOD_Leukemia

Explore this box plot interactively →