CCDC140

Across TCGA patient cohorts, CCDC140 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,489 significant associations in total. LGG shows the largest number of these associations.

The most reproducible CCDC140-associated GO terms across cancer lineages are Mitotic sister chromatid separation, Regulation of cellular response to transforming growth factor beta stimulus, and Establishment of tissue polarity. Each is linked with CCDC140 in more than 9 cancer types. Because this analysis shows association rather than direction, both CCDC140-to-partner and partner-to-CCDC140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid separation grouped by CCDC140-low versus CCDC140-high in LGG.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC140→partner) and Y-score (partner→CCDC140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Mitotic sister chromatid separation →	+0.072	+0.163	<.001	<.001	3	9
TGCT	Regulation of cellular response to transforming growth factor beta stimulus →	+0.034	+0.165	<.001	<.001	3	9
TGCT	Establishment of tissue polarity →	+0.069	+0.301	<.001	<.001	3	9
TGCT	Morphogenesis of a polarized epithelium →	+0.043	+0.172	<.001	<.001	3	8
STAD	Organelle fusion →	+0.052	+0.063	<.001	.001	2	9
LGG	Chromosome separation →	+0.071	+0.153	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,489 associations by consensus.

Mitotic sister chromatid separation by CCDC140 expression — LGG

Explore this box plot interactively →