CCDC140

Across TCGA pan-cancer cohorts, CCDC140 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CCDC140’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCDC140 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC140 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, BRCA, and LUSC are the cancer types where CCDC140 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC140 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.120	.015	8	view →
BRCA	All	All	−0.039	.002	6	view →
LUSC	Male	II,III,IV	+0.108	.020	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CCDC140–HNSC

Open the HNSC breakdown →