CCDC140

Across TCGA patient cohorts, CCDC140 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC140-associated genes across cancer lineages are PCNA, PDCD4, and ATM. Each is linked with CCDC140 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC140-to-partner and partner-to-CCDC140 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CCDC140-low versus CCDC140-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC140→partner) and Y-score (partner→CCDC140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.273	+3.584	<.001	.002	3	2
UCEC	PDCD4 →	-0.454	-1.765	.010	.014	3	2
UCEC	ATM →	-0.599	-3.906	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.093	-1.847	.014	.049	3	1
UCEC	eEF2 →	+0.345	+1.415	.010	.046	3	1
UCEC	EGFR_pY1068 →	-0.344	-3.321	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PCNA by CCDC140 expression — UCEC

Explore this box plot interactively →