CCDC136

Across TCGA patient cohorts, CCDC136 mutation is significantly associated with the RNA expression of many other genes, with 3,543 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC136-associated genes across cancer lineages are WDR41, IFI27L1, and MSANTD3. Each is linked with CCDC136 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC136-to-partner and partner-to-CCDC136 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR41 grouped by CCDC136-low versus CCDC136-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC136→partner) and Y-score (partner→CCDC136) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR41 →	+0.308	+1.369	.001	.003	3	3
UCEC	IFI27L1 →	+0.502	+3.480	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.482	+1.551	<.001	<.001	3	3
LUAD	H3P40 →	+0.112	+3.074	<.001	.005	3	3
OV	USP9YP2 →	+0.036	+5.647	<.001	<.001	3	3
LUSC	CDADC1 →	+0.399	+2.783	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,543 associations by consensus.

WDR41 by CCDC136 expression — UCEC

Explore this box plot interactively →