CCDC136

Across TCGA patient cohorts, CCDC136 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC136-associated genes across cancer lineages are eEF2, Ku80, and p38-MAPK_pT180_Y182. Each is linked with CCDC136 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC136-to-partner and partner-to-CCDC136 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CCDC136-low versus CCDC136-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC136→partner) and Y-score (partner→CCDC136) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.253	+1.700	.017	.040	3	2
UCEC	Ku80 →	+0.193	+1.391	.006	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.305	-1.514	.023	.014	3	2
UCEC	PCNA →	+0.179	+2.807	.005	.002	3	2
UCEC	TFRC →	+0.421	+1.906	.007	.014	3	2
UCEC	ATM →	-0.507	-1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by CCDC136 expression — UCEC

Explore this box plot interactively →