CCDC134

Across TCGA pan-cancer cohorts, CCDC134 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC134 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CCDC134 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC134 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where CCDC134 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.606	0.811	.004	34	view →
PDAC	DFS	Quartile	III,IV	0.588	0.174	.007	20	view →
CCRCC	DFS	Quartile	All	0.863	0.421	.014	7	view →
LUAD	OS	Median	All	0.794	0.966	.040	3	view →
UCEC	DFS	Quartile	All	1.000	0.884	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC134–HNSC (OS)

Open the HNSC breakdown →