CCDC127

Across TCGA patient cohorts, CCDC127 mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC127-associated genes across cancer lineages are SCGB1C1, RNA5SP378, and LINC00160. Each is linked with CCDC127 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC127-to-partner and partner-to-CCDC127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by CCDC127-low versus CCDC127-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC127→partner) and Y-score (partner→CCDC127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SCGB1C1 →	+0.472	+3.792	<.001	.007	3	1
COAD	RNA5SP378 →	+0.812	+4.081	.001	.004	3	1
COAD	LINC00160 →	+0.220	+3.993	<.001	.005	3	1
COAD	TBC1D26-AS1 →	+0.237	+4.624	<.001	.001	3	1
COAD	RPS15AP25 →	+0.297	+3.877	.006	.008	3	1
COAD	PTMAP6 →	+0.211	+3.870	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

SCGB1C1 by CCDC127 expression — COAD

Explore this box plot interactively →