CCDC127

Across TCGA pan-cancer cohorts, CCDC127 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CCDC127’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCDC127 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC127 is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where CCDC127 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC127 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.298	<.001	12	view →
HNSC	All	III,IV	+0.949	<.001	12	view →
LUAD	Male	All	+0.427	<.001	10	view →
LIHC	Male	II,III,IV	+0.762	<.001	9	view →
KIRP	All	II,III,IV	+0.568	<.001	7	view →
LUSC	Female	All	+0.751	<.001	6	view →
UCEC	All	All	−0.643	<.001	6	view →
THCA	All	All	−0.224	<.001	6	view →
CHOL	Male	All	+1.808	<.001	5	view →
KICH	All	All	−0.464	<.001	3	view →
BLCA	Male	IV	−0.705	.001	2	view →
COAD	All	All	+0.168	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CCDC127–KIRC

Open the KIRC breakdown →