CCDC127

Across TCGA patient cohorts, CCDC127 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC127-associated genes across cancer lineages are p62 Lck ligand, Shc_pY317, and Bim. Each is linked with CCDC127 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC127-to-partner and partner-to-CCDC127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CCDC127-low versus CCDC127-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC127→partner) and Y-score (partner→CCDC127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.489	+3.321	.004	.010	3	1
UCEC	Shc_pY317 →	-0.182	-3.321	.022	.010	3	1
UCEC	Bim →	-0.355	-3.321	.009	.010	3	1
UCEC	ERK2 →	+0.238	+3.000	.018	.036	2	1
UCEC	EGFR_pY1068 →	-0.291	-3.321	.026	.010	1	1
UCEC	ARID1A →	-0.240	-3.314	.011	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by CCDC127 expression — UCEC

Explore this box plot interactively →