Across TCGA patient cohorts, CCDC125 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC125-associated genes across cancer lineages are ASNS, 4E-BP1, and 14-3-3_beta. Each is linked with CCDC125 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC125-to-partner and partner-to-CCDC125 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC125→partner) and Y-score (partner→CCDC125) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.432	+1.584	<.001	.034	3	2
UCEC	4E-BP1 →	+0.284	+2.029	.002	.017	3	2
UCEC	14-3-3_beta →	-0.084	-1.673	.016	.040	3	1
UCEC	eIF4E →	+0.163	+2.459	.026	<.001	3	1
UCEC	INPP4B →	-0.271	-2.584	.015	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.116	-2.000	.047	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

CCDC125 survival (RNA) · tumor vs normal (RNA) · all CCDC125 data types