CCDC124

Across TCGA pan-cancer cohorts, CCDC124 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CCDC124 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CCDC124 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC124 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, OV, and LSCC are the cancer types where CCDC124 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.295	0.785	.020	12	view →
OV	DFS	Median	All	0.841	1.000	.017	8	view →
LSCC	DFS	Median	II,III,IV	0.841	0.546	.013	4	view →
GBM	OS	Median	All	0.544	0.273	.005	3	view →
LUAD	OS	Median	III,IV	0.261	0.714	.042	2	view →
PDAC	OS	Tertile	All	0.291	0.432	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CCDC124–HNSC (DFS)

Open the HNSC breakdown →