CCDC12

Across TCGA patient cohorts, CCDC12 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible CCDC12-associated genes across cancer lineages are MRPS5P4, RNU6-927P, and RN7SL714P. Each is linked with CCDC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC12-to-partner and partner-to-CCDC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS5P4 grouped by CCDC12-low versus CCDC12-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC12→partner) and Y-score (partner→CCDC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MRPS5P4 →	+0.099	+7.640	<.001	.009	3	2
COAD	RNU6-927P →	+0.921	+5.017	<.001	.009	3	2
UCEC	RN7SL714P →	+0.208	+4.267	<.001	.009	3	2
BLCA	MIR2392 →	+0.328	+7.640	<.001	.009	3	1
UCEC	RN7SL248P →	+0.168	+5.137	<.001	.003	3	1
SKCM	MIR8076 →	+0.332	+4.436	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

MRPS5P4 by CCDC12 expression — BLCA

Explore this box plot interactively →