CCDC116

Across TCGA patient cohorts, CCDC116 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC116-associated genes across cancer lineages are Caspase-7-cleavedD198, ACC1, and MEK1. Each is linked with CCDC116 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC116-to-partner and partner-to-CCDC116 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC116-low versus CCDC116-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC116→partner) and Y-score (partner→CCDC116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.336	+2.815	.002	.036	3	2
UCEC	ACC1 →	+0.289	+1.415	.034	.046	3	2
UCEC	MEK1 →	+0.415	+2.662	.002	<.001	3	2
UCEC	Rad50 →	-0.367	-3.321	<.001	<.001	3	2
UCEC	ASNS →	+0.469	+2.000	<.001	.029	3	2
UCEC	ATM →	-0.579	-2.700	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-7-cleavedD198 by CCDC116 expression — COAD

Explore this box plot interactively →