CCDC116

Across TCGA pan-cancer cohorts, CCDC116 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CCDC116 data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CCDC116 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CCDC116 expression acts as an unfavorable survival marker, although some lineages such as CESC and UCEC show a favorable association.

CESC, UCEC, and ACC are the cancer types where CCDC116 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.941	0.795	<.001	70	view →
UCEC	OS	Tertile	III,IV	0.922	0.759	.005	62	view →
ACC	DFS	Quartile	All	0.298	0.672	.002	46	view →
PAAD	DFS	Quartile	All	0.575	0.368	.003	43	view →
BLCA	OS	Tertile	III,IV	0.403	0.712	.002	26	view →
TGCT	DFS	Quartile	All	0.601	0.892	.003	18	view →
GBM	DFS	Quartile	All	0.359	0.185	.005	16	view →
PRAD	DFS	Quartile	All	0.823	0.948	<.001	12	view →
OV	OS	Median	All	0.273	0.368	.020	8	view →
READ	OS	Median	II,III,IV	1.000	0.835	.003	7	view →
SKCM	DFS	Median	IV	0.660	0.155	.031	7	view →
KIRC	DFS	Quartile	II,III,IV	0.387	0.609	.008	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CCDC116–CESC (OS)

Open the CESC breakdown →