CCDC116

Across TCGA cell cohorts, CCDC116 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC116-associated genes across cancer lineages are MAGEB4, FIGLA, and OR4F4. Each is linked with CCDC116 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC116-to-partner and partner-to-CCDC116 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CCDC116-low versus CCDC116-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC116→partner) and Y-score (partner→CCDC116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	2
BLOOD_Leukemia	FIGLA →	+0.015	+4.247	<.001	.004	3	2
SKIN	OR4F4 →	+0.059	+3.725	.002	.008	3	2
OESOPHAGUS	PRAMEF12 →	+0.005	+3.392	<.001	.007	3	1
OESOPHAGUS	OR8B12 →	+0.048	+3.392	<.001	.007	3	1
OESOPHAGUS	CYP4A11 →	+0.020	+4.115	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

MAGEB4 by CCDC116 expression — LARGE_INTESTINE

Explore this box plot interactively →