CCDC115

Across TCGA patient cohorts, CCDC115 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC115-associated genes across cancer lineages are RNA5SP419, RNA5SP410, and CLEC12A. Each is linked with CCDC115 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC115-to-partner and partner-to-CCDC115 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by CCDC115-low versus CCDC115-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC115→partner) and Y-score (partner→CCDC115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP419 →	+1.055	+3.077	<.001	.001	3	2
UCEC	RNA5SP410 →	+1.026	+2.789	<.001	.004	3	2
UCEC	CLEC12A →	+0.567	+3.255	.001	.009	3	1
ESCA	C4B-AS1 →	+0.016	+6.709	<.001	<.001	3	1
ESCA	RNU7-144P →	+0.360	+5.681	<.001	.003	3	1
UCEC	RNA5SP414 →	+1.004	+3.255	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

RNA5SP419 by CCDC115 expression — UCEC

Explore this box plot interactively →