CCDC115

Across TCGA pan-cancer cohorts, CCDC115 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CCDC115’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCDC115 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC115 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, HNSC, and LUAD are the cancer types where CCDC115 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC115 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.440	<.001	10	view →
HNSC	All	III,IV	+0.535	<.001	9	view →
LUAD	All	III,IV	−0.418	<.001	9	view →
THCA	All	IV	−0.384	<.001	8	view →
LIHC	Female	All	+0.605	<.001	7	view →
UCEC	All	All	−0.748	<.001	6	view →
CHOL	Female	All	+1.966	<.001	5	view →
PRAD	All	All	−0.395	<.001	2	view →
KIRC	All	All	+0.195	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CCDC115–KICH

Open the KICH breakdown →