CCDC115

Across TCGA patient cohorts, CCDC115 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC115-associated genes across cancer lineages are MEK1, MSH6, and CD49b. Each is linked with CCDC115 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC115-to-partner and partner-to-CCDC115 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CCDC115-low versus CCDC115-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC115→partner) and Y-score (partner→CCDC115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.481	+3.000	.023	.037	3	1
UCEC	MSH6 →	-0.477	-3.000	.012	.037	3	1
UCEC	CD49b →	-0.385	-2.980	.019	.036	3	1
UCEC	Cyclin-B1 →	+0.745	+3.000	.021	.037	3	1
UCEC	Annexin-1 →	+0.830	+3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by CCDC115 expression — UCEC

Explore this box plot interactively →