CCDC114

Across TCGA pan-cancer cohorts, CCDC114 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CCDC114 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CCDC114 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC114 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC and LUAD are the cancer types where CCDC114 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.825	0.435	.028	4	view →
LUAD	OS	Tertile	II,III,IV	0.821	0.350	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CCDC114–LSCC (DFS)

Open the LSCC breakdown →