CCDC114

Across TCGA pan-cancer cohorts, CCDC114 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCDC114’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CCDC114 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC114 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

COAD, LUAD, and BLCA are the cancer types where CCDC114 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC114 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.356	<.001	9	view →
LUAD	All	All	−1.118	<.001	7	view →
BLCA	All	All	+0.482	.002	7	view →
LUSC	Female	All	−1.241	<.001	6	view →
BRCA	All	II,III,IV	+0.379	<.001	6	view →
LIHC	Male	All	+0.169	<.001	6	view →
CHOL	Male	All	+1.556	<.001	4	view →
KIRP	Male	All	−0.266	.002	3	view →
READ	Female	All	+0.449	.013	2	view →
THCA	All	All	−0.217	.010	2	view →
HNSC	Male	III,IV	+0.311	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CCDC114–COAD

Open the COAD breakdown →