CCDC114

Across TCGA patient cohorts, CCDC114 mutation is significantly associated with the RNA expression of many other genes, with 952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC114-associated genes across cancer lineages are RNU6-1112P, CYB5AP4, and MTND3P24. Each is linked with CCDC114 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC114-to-partner and partner-to-CCDC114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1112P grouped by CCDC114-low versus CCDC114-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC114→partner) and Y-score (partner→CCDC114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1112P →	+0.382	+4.505	<.001	.009	3	2
HNSC	CYB5AP4 →	+0.532	+5.025	<.001	.002	3	2
CESC	MTND3P24 →	+0.055	+4.579	<.001	.003	3	2
CESC	RNA5SP401 →	+0.222	+4.252	<.001	.006	3	2
CESC	GLRXP2 →	+0.065	+3.802	<.001	.002	3	2
CESC	MIR4769 →	+0.173	+4.579	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 952 associations by consensus.

RNU6-1112P by CCDC114 expression — HNSC

Explore this box plot interactively →