CCDC114

Across TCGA patient cohorts, CCDC114 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC114-associated genes across cancer lineages are ATM, Myosin-IIa_pS1943, and p62 Lck ligand. Each is linked with CCDC114 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC114-to-partner and partner-to-CCDC114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CCDC114-low versus CCDC114-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC114→partner) and Y-score (partner→CCDC114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATM →	-0.464	-3.321	.023	.010	3	2
UCEC	Myosin-IIa_pS1943 →	+0.203	+1.861	.007	.005	3	1
UCEC	p62 Lck ligand →	+0.348	+1.817	.003	.015	3	1
UCEC	PI3K-p85 →	+0.154	+1.874	.044	.049	3	1
UCEC	Rab25 →	-0.264	-3.321	.030	.009	3	1
UCEC	S6_pS240_S244 →	+0.334	+2.115	.025	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by CCDC114 expression — SKCM

Explore this box plot interactively →