CCDC114

Across TCGA cell cohorts, CCDC114 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CCDC114-associated genes across cancer lineages are DEFB134, DYDC1, and GALP. Each is linked with CCDC114 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC114-to-partner and partner-to-CCDC114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB134 grouped by CCDC114-low versus CCDC114-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC114→partner) and Y-score (partner→CCDC114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DEFB134 →	+0.182	+4.169	<.001	.008	3	2
URINARY_TRACT	DYDC1 →	+0.073	+5.087	<.001	.004	3	1
URINARY_TRACT	GALP →	+0.036	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	OR5G3 →	+0.030	+4.867	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.334	+3.252	<.001	.009	3	1
LARGE_INTESTINE	ETNPPL →	+0.172	+3.938	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

DEFB134 by CCDC114 expression — CNS

Explore this box plot interactively →