CCDC112

Across TCGA cell cohorts, CCDC112 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CCDC112-associated genes across cancer lineages are OR2V1, TEX26, and PIGY. Each is linked with CCDC112 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC112-to-partner and partner-to-CCDC112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2V1 grouped by CCDC112-low versus CCDC112-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC112→partner) and Y-score (partner→CCDC112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2V1 →	+0.033	+3.510	.006	.003	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.035	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PIGY →	+1.354	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP7-1 →	+0.181	+4.887	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	HTN3 →	+0.079	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	SLC5A8 →	+0.012	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR2V1 by CCDC112 expression — LARGE_INTESTINE

Explore this box plot interactively →