CCDC110

Across TCGA patient cohorts, CCDC110 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC110-associated genes across cancer lineages are Ku80, Caspase-7-cleavedD198, and p27_pT198. Each is linked with CCDC110 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC110-to-partner and partner-to-CCDC110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CCDC110-low versus CCDC110-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC110→partner) and Y-score (partner→CCDC110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Ku80 →	+0.396	+3.027	.025	.018	3	3
UCEC	Caspase-7-cleavedD198 →	+0.418	+2.242	.038	.005	3	3
UCEC	p27_pT198 →	+0.090	+1.807	.014	.004	3	2
UCEC	p62 Lck ligand →	+0.330	+1.807	.002	.004	3	2
UCEC	Annexin-1 →	+0.490	+2.242	.006	.005	3	2
UCEC	Cyclin-E2 →	+0.125	+1.247	.029	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Ku80 by CCDC110 expression — LUSC

Explore this box plot interactively →