CCDC110

Across TCGA pan-cancer cohorts, CCDC110 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CCDC110’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC110 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC110 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, KIRC, and BLCA are the cancer types where CCDC110 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC110 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.100	<.001	11	view →
KIRC	All	All	+0.538	<.001	9	view →
BLCA	Male	IV	−1.225	<.001	8	view →
LIHC	Male	All	+0.399	<.001	7	view →
STAD	Male	II,III,IV	−0.629	.004	6	view →
LUAD	All	All	+0.430	<.001	5	view →
UCEC	All	All	−0.883	<.001	4	view →
KIRP	All	II,III,IV	+0.541	.007	4	view →
CHOL	All	All	+0.533	.001	4	view →
COAD	Female	All	−0.389	.010	4	view →
HNSC	Male	All	−0.378	.004	4	view →
PRAD	All	All	+1.014	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CCDC110–THCA

Open the THCA breakdown →