CCDC110

Across TCGA cell cohorts, CCDC110 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC110-associated genes across cancer lineages are FAM170B, DHRS7C, and RSPH6A. Each is linked with CCDC110 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC110-to-partner and partner-to-CCDC110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM170B grouped by CCDC110-low versus CCDC110-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC110→partner) and Y-score (partner→CCDC110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM170B →	+0.135	+4.981	<.001	.008	3	1
OVARY	DHRS7C →	+0.307	+5.196	<.001	.005	3	1
LARGE_INTESTINE	RSPH6A →	+0.097	+2.688	.002	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.349	+3.474	<.001	.003	3	1
LARGE_INTESTINE	P3H3 →	+1.628	+3.212	.004	.006	3	1
LARGE_INTESTINE	CLCC1 →	+0.680	+3.212	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

FAM170B by CCDC110 expression — CNS

Explore this box plot interactively →